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After the macrophagesclean the wound and make it ready for tissue repair epithelial cells move from the wound margins under the base of the clot or scab.Epithelial cells continue to gather under the wound space for about 48 hours.Eventually a thin layer of epithelial tissue forms over the wound as a barrier against infectious organisms and toxic materials.Growth hormones are released by platelets and macrophages.There is increasing evidence that these factors promote wound healing.The inflammatory phase is prolonged and repair processes are slowed if too little inflammation occurs as in debilitating disease or after administration of steroids.

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